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| Registros recuperados : 12 | |
| 3. |  | PAIVA, C. L.; VIANA, A. P.; SANTOS, E. A.; FREITAS, J. C. de O.; SILVA, R. N. O.; OLIVEIRA, E. J. de. Genetic variability assessment in the genus Passiflora by SSR markers. Chilean Journal of Agricultural Research, v. 74, n.3, July/September, 2014.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 4. | | PAIVA, C. L.; VIANA, A. P.; SILVA, R. N. O.; SANTOS, E. A.; FREITAS, J. C. de O.; OLIVEIRA, E. J. de. Diversidade genética entre acessos de espécies de passiflora utilizando caracteres morfológicos. In: CONGRESSO BRASILEIRO DE FRUTICULTURA, 22., 2012, Bento Gonçalves. Anais... Bento Gonçalves: SBF, 2012.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 5. | | FREITAS, J. C. de; POZZER, L.; REZENDE, J. A. M.; KITAJIMA, E. W.; AVILA, A. C. de; RESENDE, R. de O. Lisianthus: a new ornamental affected by tomato spotted wilt virus in Brazil. Fitopatologia Brasileira, Brasilia, v.22, n.1, p.114, mar. 1997.| Biblioteca(s): Embrapa Hortaliças. |
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| 6. | | MULLER, E. E.; NASCIMENTO, E. R. do; METTIFOGO, E.; REIS, A. C. F. dos; FREITAS, J. C. de; NASCIMENTO, M. da G. F. do. Isolamento de Mycoplasma arginini E Actinomyces pyogenes de ovino com pleuropneumonia. Revista Brasileira de Medicina Veterinaria, v.20, n.3, p.118-119, 1998.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 7. | | OLIVEIRA, J. S.; FERNANDES, S. C. R.; SCHWARTZ, C. A.; BLOCH JUNIOR, C.; MELO, J. A. T.; PIRES JUNIOR, O. R.; FREITAS, J. C. de. Toxicity and toxin identification in Colomesus asellus, an Amazonian (Brazil) freshwater puffer fish. Toxicon, v. 48, p. 55-63, 2006.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 9. | | HASHIMOTO, V. Y.; DIAS, J. A.; CHIDEROLI, R. T.; BARBARA, J. C. A.; BUNHARO, T. B.; DUTRA, L. H.; SILVA, M. do C. P.; MULLER, E. E.; FREITAS, J. C. de. Epidemiological status of bovine leptospirosis in the State of Paraná, Brazil. Semina: Ciências Agrárias, Londrina, v. 36, n. 6, suplemento 2, p. 4341-4356, 2015.| Biblioteca(s): Embrapa Rondônia. |
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| 10. | | OLIVEIRA, E. B. de; SOUSA, L. P. de; FROUFE, L. C. M.; AGUIAR, A. V. de; LEMBERGER, E.; SANTOS, L. M. F. dos; FREITAS, J. C. de; GOBOR, D.; SCHAITZA, E. G.; MAXIMIANO, G. A.; CHANG, M. Avaliação de uma floresta de espécies nativas formada em sub-bosque de plantação de eucalipto, no noroeste do Estado do Paraná. In: SEMINÁRIO NACIONAL SOBRE DINÂMICAS DE FLORESTAS, 1., 2008, Curitiba. Anais. Colombo: Embrapa Florestas, 2008. 1 CD-ROM. Resumo 49.| Biblioteca(s): Embrapa Florestas. |
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| 11. | | SILVA, N. P. da; PEREIRA, E. do C. R. L.; DUARTE, L. M.; FREITAS, J. C. de O.; ALMEIDA, C. G. de; SILVA, T. P. da; MELO, R. C. N.; APOLONIO, A. C. M.; OLIVEIRA, M. A. L. de; BRANDAO, H. de M.; PITTELLA, F.; FABRI, R. L.; TAVARES, G. D.; PINTO, P. de F. Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules. Colloids and Surfaces B: Biointerfaces, v. 196, 111371, 2020.| Biblioteca(s): Embrapa Gado de Leite. |
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| 12. | | SCHAITZA, E. G.; SHANG, M.; OLIVEIRA, E. B. de; LIMBERGER, E.; SANTOS, L. M. F. dos; SHIMIZU, J. Y.; GOBOR, D.; SIQUEROLO, E. F.; MAXIMIANO, G. A.; AGUIAR, A. V. de; SOUSA, L. P. de; BIANCO, A. de J.; SANTOS, E. S. dos; PASSARELLI, I.; FREITAS, J. C. de; DOMINGUES, R.; GONÇALVES, A. R.; GARBELINI, W. A.; SANTOS, J. F. dos; MORIS, A. C.; SABOT, A. L.; SANTOS, A. S. dos. Implantação e manejo de florestas em pequenas propriedades no Estado do Paraná: um modelo para a conservação ambiental, com inclusão social e viabilidade econômica. Colombo: Embrapa Florestas, 2008. 49 p. (Embrapa Florestas. Documentos, 167).| Biblioteca(s): Embrapa Cerrados; Embrapa Florestas; Embrapa Mandioca e Fruticultura; Embrapa Unidades Centrais. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
21/08/2021 |
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Data da última atualização: |
21/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SILVA, N. P. da; PEREIRA, E. do C. R. L.; DUARTE, L. M.; FREITAS, J. C. de O.; ALMEIDA, C. G. de; SILVA, T. P. da; MELO, R. C. N.; APOLONIO, A. C. M.; OLIVEIRA, M. A. L. de; BRANDAO, H. de M.; PITTELLA, F.; FABRI, R. L.; TAVARES, G. D.; PINTO, P. de F. |
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Afiliação: |
NATALIA PRADO DA SILVA, Universidade Federal de Juiz de Fora; ELOA DO CARMO RAPOZO LAVINAS PEREIRA, Universidade Federal de Juiz de Fora; LUCAS MATTOS DUARTE, Universidade Federal de Juiz de Fora; JHAMINE CAROLINE DE OLIVEIRA FREITAS, Universidade Federal de Juiz de Fora; CAMILA GUIMARAES DE ALMEIDA; THIAGO PEREIRA DA SILVA, Universidade Federal de Juiz de Fora; ROSSANA C. N. MELO, Universidade Federal de Juiz de Fora; ANA CAROLINA MORAIS APOLONIO, Universidade Federal de Juiz de Fora; MARCONE AUGUSTO LEAL DE OLIVEIRA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; FREDERICO PITTELLA, Universidade Federal de Juiz de Fora; RODRIGO LUIZ FABRI, Universidade Federal de Juiz de Fora; GUILHERME DINIZ TAVARES, Universidade Federal de Juiz de Fora; PRISCILA DE FARIA PINTO, Universidade Federal de Juiz de Fora. |
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Título: |
Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Colloids and Surfaces B: Biointerfaces, v. 196, 111371, 2020. |
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DOI: |
https://doi.org/10.1016/j.colsurfb.2020.111371 |
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Idioma: |
Inglês |
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Conteúdo: |
The purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore, chitosan-poly(?-caprolactone) core-shell nanocapsules are a promising tool for TTO delivery, aiming at the activity against C. acnes for the topical acne treatment. MenosThe purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore... Mostrar Tudo |
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Palavras-Chave: |
Acne vulgaris; Core-shell nanocapsules; Nanocápsula; Quitosana-poli. |
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Thesagro: |
Árvore. |
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Thesaurus NAL: |
Chitosan; Tea tree oil. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02808naa a2200373 a 4500
001 2133785
005 2021-08-21
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.colsurfb.2020.111371$2DOI
100 1 $aSILVA, N. P. da
245 $aImproved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules.$h[electronic resource]
260 $c2020
520 $aThe purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore, chitosan-poly(?-caprolactone) core-shell nanocapsules are a promising tool for TTO delivery, aiming at the activity against C. acnes for the topical acne treatment.
650 $aChitosan
650 $aTea tree oil
650 $aÁrvore
653 $aAcne vulgaris
653 $aCore-shell nanocapsules
653 $aNanocápsula
653 $aQuitosana-poli
700 1 $aPEREIRA, E. do C. R. L.
700 1 $aDUARTE, L. M.
700 1 $aFREITAS, J. C. de O.
700 1 $aALMEIDA, C. G. de
700 1 $aSILVA, T. P. da
700 1 $aMELO, R. C. N.
700 1 $aAPOLONIO, A. C. M.
700 1 $aOLIVEIRA, M. A. L. de
700 1 $aBRANDAO, H. de M.
700 1 $aPITTELLA, F.
700 1 $aFABRI, R. L.
700 1 $aTAVARES, G. D.
700 1 $aPINTO, P. de F.
773 $tColloids and Surfaces B: Biointerfaces$gv. 196, 111371, 2020.
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